Alexandria Digital Research Library

Blood-Cell Inspired Polymeric Drug Delivery Systems

Author:
Anselmo, Aaron C.
Degree Grantor:
University of California, Santa Barbara. Chemical Engineering
Degree Supervisor:
Samir Mitragotri
Place of Publication:
[Santa Barbara, Calif.]
Publisher:
University of California, Santa Barbara
Creation Date:
2015
Issued Date:
2015
Topics:
Engineering, Chemical, Health Sciences, Pharmacy, and Nanoscience
Keywords:
Polymeric Nanoparticles
Drug Delivery
Blood Cells
Circulation
Nanoparticles
Targeted Delivery
Genres:
Dissertations, Academic and Online resources
Dissertation:
Ph.D.--University of California, Santa Barbara, 2015
Description:

Polymeric carriers are a promising drug delivery system that are poised to treat numerous diseases, provided their abilities to control drug release and target specific parts of the body are successfully translated. The main issues preventing successful translation of polymeric carriers into the clinic includes poor vascular circulation, limited targeting and the inability to negotiate many biological barriers. Furthermore, multifunctional carriers capable of combining these functions have yet to be demonstrated. However, it is theoretically possible to design such multifunctional carriers as circulatory cells are capable of performing these same functions. During my Ph.D, I have developed three distinct blood-cell inspired drug delivery systems that improve the in vivo delivery abilities of polymeric carriers by utilizing and mimicking many of the abilities of the main individual cellular components in blood, namely: (i) erythrocytes, (ii) leukocytes and (iii) thrombocytes. The first two examples utilize a strategy known as "cellular hitchhiking", which involves the attachment of polymeric particles to the surface of circulatory cells so as to transfer innate circulatory and targeting abilities from cell to particle. The second strategy involves the design and application of synthetic platelets, dubbed platelet like nanoparticles (PLNs), which incorporate the essential biophysical (shape and flexibility) and biochemical (surface biology) parameters of natural platelets into a polymeric nanoparticle.

Physical Description:
1 online resource (143 pages)
Format:
Text
Collection(s):
UCSB electronic theses and dissertations
ARK:
ark:/48907/f398855p
ISBN:
9781321695540
Catalog System Number:
990045119220203776
Rights:
Inc.icon only.dark In Copyright
Copyright Holder:
Aaron Anselmo
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