Alexandria Digital Research Library

Adhesion and detachment of capsules in flow

Author:
Keh, Martin Peilien
Degree Grantor:
University of California, Santa Barbara. Chemical Engineering
Degree Supervisor:
Gary Leal and Todd Squires
Place of Publication:
[Santa Barbara, Calif.]
Publisher:
University of California, Santa Barbara
Creation Date:
2015
Issued Date:
2015
Topics:
Chemical engineering
Keywords:
Boundary Integral
Stokes flow
Adhesion
Surface force
Capsule
Peeling
Genres:
Dissertations, Academic and Online resources
Dissertation:
Ph.D.--University of California, Santa Barbara, 2015
Description:

In the present study, adhesion and detachment between a capsule and a rigid stationary boundary are investigated theoretically, numerically and experimentally. We have developed a numerical model coupling the boundary integral method for the motion of the fluids, a finite element method for the membrane mechanics and the Derjaguin approximation for the surface forces acting between the membrane and the solid boundary. Simulation results for the dynamics of thin film drainage, equilibrium contact radius and the dynamics of peeling of an adhered capsule under flow are reported and compared to scaling theories. We also experimentally investigated the adhesion and detachment of human serum albumin (HSA) capsules to a rigid stationary cylinder in a rectangular polydimethylsiloxane (PDMS) channel with a pressure driven flow. The strength of adhesion between the capsule membrane and the cylinder is controlled by varying the concentration of a non-adsorbing polyelectrolyte in the suspending fluid which induces attractive depletion forces when the gap between the two surfaces is smaller than the size of the polyelectrolyte.

Physical Description:
1 online resource (178 pages)
Format:
Text
Collection(s):
UCSB electronic theses and dissertations
ARK:
ark:/48907/f3891429
ISBN:
9781339218663
Catalog System Number:
990045865580203776
Rights:
Inc.icon only.dark In Copyright
Copyright Holder:
Martin Keh
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